Structure Before Intelligence: Gating What Agentic Scientific Workflows Release
cs.AI, q-bio.QM
Submitted: 2026-10-14
Updated: 2026-10-14
Comments: 21 pages: 10-page main paper and 11-page supplement; 2 figures
License: http://creativecommons.org/licenses/by/4.0/
The gist: An agentic scientific workflow can run to completion and still release wrong results: a silent numerical error, a stale input, or a defect in a shared upstream step can contaminate several outputs
Abstract
An agentic scientific workflow can run to completion and still release wrong results: a silent numerical error, a stale input, or a defect in a shared upstream step can contaminate several outputs while a sibling branch stays correct. We treat trust in such results as a release decision. A harness around the workflow's directed acyclic graph (DAG) decides which outputs may be used: it enforces mandatory checks, contains failures to the affected branch, recomputes from tracked versions, adds validators, and releases a result only if a risk model estimates its probability of being invalid as low. Language-model agents work inside the harness, choosing corrective actions and reviewing releases, but cannot override it. On 60 held-out paired instances of two workflows with injected faults, we switched components on and off. Each supplied a different property. Containment and recovery raised the number of correct results. Validation supplied safety: fixed rules without validation released 37 invalid results, while validating every candidate released none. Risk estimation supplied efficiency, matching that safety with 31% fewer validators at somewhat lower yield, although better targeting than random validation was not shown. Lineage evidence helped on one workflow. The language model added no measurable benefit: whether invalid results escaped depended on the harness, not the model. This proof of concept points to a practical path: placing agents inside explicit release-control structure can keep released scientific results trustworthy, and it gives more capable agents a measurable baseline to improve on.
Related papers
- MAVEN-T: Reinforced Heterogeneous Distillation for Real-Time Multi-Agent Trajectory Prediction
- Model Discovery Agent: LLM-assisted Bayesian experiment design for data-efficient discovery of mechanistic world models
- Agents' Last Exam
- The Clinician's Veto: Navigating Trust, Liability, and Uncertainty in Autonomous AI Prescribing
- MindHelper: Closed-Loop Embodied Mental-State Reasoning for Precision Intervention
- Incumbent Advantage: Brand Bias and Cognitive Manipulation Dynamics in LLM Recommendation Systems