Enforcing Thermodynamic Consistency in Parameter Optimization and Bayesian Inference of Biochemical Reaction Networks

arXiv:2610.17155 · q-bio.MN, q-bio.SC · Submitted 2026-10-12 · Read on arXiv

q-bio.MN, q-bio.SC

Submitted: 2026-10-12

Updated: 2026-10-12

Comments: 22 pages, 8 figures

License: http://arxiv.org/licenses/nonexclusive-distrib/1.0/

Terminology

• Consistency — 2× in this paper · explained in 3 episodes
• Bayesian Inference — 1× in this paper · explained in 5 episodes
• Conservation Laws — 1× in this paper · explained in 3 episodes
• Uncertainty Quantification — 1× in this paper · explained in 9 episodes

Related papers

• Triangularity of the Jacobian on siphon faces, the Metzler property of its transversal component and other results
• Latent Causal Diffusions for Single-Cell Perturbation Modeling
• Tracking large chemical reaction networks and rare events by neural networks
• Synergy and Complementarity: The Generative Basis of Chemical Organizations