RipplePLM: Structural and Property Decoupling for Protein Mutation Effect Generation

arXiv:2610.01891 · cs.CE, q-bio.BM · Submitted 2026-10-01 · Read on arXiv

cs.CE, q-bio.BM

Submitted: 2026-10-01

Updated: 2026-10-03

Code: https://github.com/Lyu6PosHao/RipplePLM

Terminology

• Ablation — 9× in this paper · explained in 1 episode
• Benchmark — 8× in this paper · explained in 2 episodes
• Mutation Perturbation Field — 5× in this paper
• Adaptation — 4× in this paper · explained in 1 episode
• Decoupling — 4× in this paper · explained in 2 episodes
• Generalization — 4× in this paper · explained in 13 episodes
• Transformer — 4× in this paper · explained in 2 episodes
• Alignment — 3× in this paper · explained in 1 episode
• Embeddings — 3× in this paper · explained in 2 episodes
• Latent Representation — 3× in this paper · explained in 2 episodes
• Pseudo-labels — 3× in this paper · explained in 2 episodes
• Regularization — 3× in this paper · explained in 3 episodes
• Ablation Studies — 2× in this paper · explained in 1 episode
• Accuracy — 2× in this paper · explained in 1 episode
• Core — 2× in this paper · explained in 2 episodes
• Direct-Distal Cross-Attention — 2× in this paper
• Generative Model — 2× in this paper · explained in 2 episodes
• Generative Models — 2× in this paper · explained in 2 episodes
• Latent Representations — 2× in this paper · explained in 3 episodes
• LoRA Adapters — 2× in this paper · explained in 3 episodes
• Ontology — 2× in this paper · explained in 2 episodes
• Representation Learning — 2× in this paper · explained in 2 episodes
• Ablation study — 1× in this paper · explained in 1 episode
• Adam — 1× in this paper · explained in 2 episodes
• Aggregation — 1× in this paper · explained in 1 episode
• Chain-of-Thought Prompting — 1× in this paper · explained in 2 episodes
• Clustering — 1× in this paper · explained in 2 episodes
• Computational Biology — 1× in this paper · explained in 2 episodes
• Distribution Shift — 1× in this paper · explained in 5 episodes
• Failure Modes — 1× in this paper · explained in 3 episodes
• Fidelity — 1× in this paper · explained in 2 episodes
• Fine-Tuning — 1× in this paper · explained in 5 episodes
• GNNs — 1× in this paper · explained in 2 episodes
• Grounding — 1× in this paper · explained in 3 episodes
• Hallucination — 1× in this paper · explained in 3 episodes
• Information Leakage — 1× in this paper · explained in 2 episodes
• Linear probe — 1× in this paper · explained in 2 episodes
• Parameter-Efficient Fine-Tuning — 1× in this paper · explained in 2 episodes
• Reinforcement Learning — 1× in this paper · explained in 4 episodes
• Robustness — 1× in this paper · explained in 5 episodes
• Trace — 1× in this paper · explained in 2 episodes
• Transfer Learning — 1× in this paper · explained in 10 episodes

Sources

• Understanding intermediate layers using linear classifier probes
• Galactica: A Large Language Model for Science
• GPT-4 Technical Report
• How to Detect and Defeat Molecular Mirage: A Metric-Driven Benchmark for Hallucination in LLM-based Molecular Comprehension

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