CPTCs Drive Somatic-Visceral Communication via the Wnt Axis in Somatic Mechanotherapy: A Single-Cell Deep Learning Study
Researchers used a deep learning framework to find CD34+PDGFRα+ telocytes (CPTCs) as key mechanosensors in fascia and colon during colitis. They found that somatic mechanical stimulation triggers a signaling cascade in fascial CPTCs, which then causes a 'transcriptional resonance' in colonic CPTCs via the Wnt axis, reprogramming them for tissue repair.