ProMORNA: An End-to-End Generative Framework for Full-Length mRNA Design

Name: ProMORNA: An End-to-End Generative Framework for Full-Length mRNA Design
Uploaded: 2026-10-23T10:33:52.511990+00:00
Duration: 373 s
Description: ProMORNA is an end-to-end framework that generates complete mRNA transcripts directly from a target protein sequence. It uses a BART model and Multi-Objective Group Relative Policy Optimization (MO-GRPO) to simultaneously optimize five biological goals, such as predicted half-life and translation efficiency, leading to better mRNA designs than existing methods.

ProMORNA is an end-to-end framework that generates complete mRNA transcripts directly from a target protein sequence. It uses a BART model and Multi-Objective Group Relative Policy Optimization (MO-GRPO) to simultaneously optimize five biological goals, such as predicted half-life and translation efficiency, leading to better mRNA designs than existing methods.

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