Validation of a Computational Respiratory System Model for Mechanical Ventilation
This study validated a computational model simulating a patient and ventilator system for automated weaning protocols in mechanical ventilation. Using ASME V&V 40 and FDA principles, researchers assessed the model's credibility for medium-low risk use cases. The results confirm the model is 'fit for purpose' to predict key respiratory parameters like tidal volume and CO2 levels during preclinical in silico trials.